Regulation of Caspase-8 Activity at the Crossroads of Pro-Inflammation and Anti-Inflammation |
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Authors: | Jun-Hyuk Han Jooho Park Tae-Bong Kang Kwang-Ho Lee |
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Affiliation: | 1.Department of Applied Life Sciences, Graduate School, BK21 Program, Konkuk University, Chungju 27478, Korea; (J.-H.H.); (J.P.); (K.-H.L.);2.Department of Biomedical Chemistry, College of Biomedical & Health Science, Konkuk University, Chungju 27487, Korea;3.Department of Biotechnology, College of Biomedical & Health Science, Konkuk University, Chungju 27487, Korea |
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Abstract: | Caspase-8 has been classified as an apoptotic caspase, and its initial definition was an initiator of extrinsic cell death. During the past decade, the concept of caspase-8 functioning has been changed by findings of its additional roles in diverse biological processes. Although caspase-8 was not originally thought to be involved in the inflammation process, many recent works have determined that caspase-8 plays an important role in the regulatory functions of inflammatory processes. In this review, we describe the recent advances in knowledge regarding the manner in which caspase-8 modulates the inflammatory responses concerning inflammasome activation, cell death, and cytokine induction. |
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Keywords: | caspase-8 inflammasome inflammation necroptosis pyroptosis apoptosis |
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