|
|||||
|
|
Idiosyncratic Drug Induced Liver Injury,Cytochrome P450, Metabolic Risk Factors and Lipophilicity: Highlights and Controversies |
|
| Authors: | Rolf Teschke Gaby Danan |
| Affiliation: | 1.Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, D-63450 Hanau, Academic Teaching Hospital of the Medical Faculty, Goethe University Frankfurt/Main, 60323 Frankfurt/Main, Germany;2.Pharmacovigilance Consultancy, F-75020 Paris, France; |
| Abstract: | |
| Keywords: | cytochrome P450 CYP isoforms DILI daily drug dose iDILI idiosyncratic drug induced liver injury drug metabolism lipophilicity metabolic risk factors reactive oxygen species (ROS) Roussel Uclaf Causality Assessment Method RUCAM |