Molecular Mechanism of Cannabinoids in Cancer Progression |
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| Authors: | Cristina Pagano Giovanna Navarra Laura Coppola Maurizio Bifulco Chiara Laezza |
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| Affiliation: | 1.Department of Molecular Medicine and Medical Biotechnology, University of Naples “Federico II”, Via Pansini 5, 80131 Naples, Italy; (C.P.); (G.N.); (L.C.);2.Institute of Endocrinology and Experimental Oncology, IEOS CNR, Via Pansini 5, 80131 Naples, Italy |
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| Abstract: | Cannabinoids are a family of heterogeneous compounds that mostly interact with receptors eliciting several physiological effects both in the central and peripheral nervous systems and in peripheral organs. They exert anticancer action by modulating signaling pathways involved in cancer progression; furthermore, the effects induced by their use depend on both the type of tumor and their action on the components of the endocannabinoid system. This review will explore the mechanism of action of the cannabinoids in signaling pathways involved in cancer proliferation, neovascularisation, migration, invasion, metastasis, and tumor angiogenesis. |
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| Keywords: | cannabinoids cell death migration angiogenesis cancer |
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