The effects of midazolam on oxygen consumption and the level of vigilance. The possibility of the sedative effect of the plexiglas dome (canopy) of the Deltatrac indirect calorimetry device |
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Authors: | F Kerbaul JC Dumont N Bruder P Auquier G Fran?ois |
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Affiliation: | Department of Anesthesiology, Osaka Medical College, Takatsuki. |
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Abstract: | We investigated the effect of intravenous magnesium, a N-methyl-D-asparate (NMDA) receptor antagonist, in 8 patients suffering from neuropathic pain (post herpetic neuralgia or causalgia etc.). After the nerve block, magnesium sulphate (0.5 mol.l-1) 5 ml was administered intravenously by bolus infusion taking 5 min, followed by continuous infusion of the same dose for one hour. All patients were treated with this therapy once a week. In 4 patients, VAS score decreased 3 points or more when this therapy had been administered 3 to 11 times. In 2 patients, VAS score did not change, and the analgesic effect of magnesium was not certain in other 2 patients. Some patients felt heat sensation immediately after the bolus infusion of Mg, and had a good sleep after this therapy. However, there were not any severe side effects and significant change in HR or BP. We conclude that this therapy with magnesium once a week is safe and effective for relieving neuropathic pain. |
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