内源乳化凝胶法制备微米级海藻酸微胶囊的研究

内源乳化凝胶法中的一些物理化学参数(海藻酸钠浓度,乳化剂用量,水与油体积比等)影响海藻酸微胶囊的大小及粒径分布,文中对这些物理化学参数进行了研究。实验表明:微胶囊的平均粒径随着内部水油相体积比的增高和乳化剂Span80用量的增大而减小,随着海藻酸钠浓度的增大而增大。制备平均粒径为40～60μm海藻酸微胶囊的最佳工艺条件是:海藻酸钠浓度为15g/L,乳化剂Span 80用量为0.7%,水与油的体积比为1:8,CaCO_3与NaALG质量比为1:5。内源乳化凝胶法对大规模生产较小粒径的微胶囊有广阔的前景。

Studies on the Production of Micron-size Alginate Beads by Emulsification/Internal Gelation

Some physico-chemical parameters(alginate concentration,emulsifier concentration,internal water to oil ratio)which influenced the production and size of alginate beads in emulsification-internal gela- tion method were researched.The diameter decreased with the increasing of internal ratio of water to oil,e- mulsifier Span80 concentration,but increased with the increasing of alginate concentration.The results showed that the optimal conditions for the production of alginate beads with the mean diameter of 40～60μm were:alginate concentration 1.5%(w/v),emulsifier Span80 concentration 0.7%(v/v),the ratio of water to oil 1:8(v/v)and the ratio of CaCO_3 to NaALG 1:5(w/w),The results demonstrated that the emulsifica- tion-internal gelation was promising for large-scale immobilization.