| 含硅二烃基锡二吡啶羧酸酯的合成与结构表征 |
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| 引用本文： | 林森,邓检阳,江玉春,邓瑞红,揭克敏,高明. 含硅二烃基锡二吡啶羧酸酯的合成与结构表征[J]. 化学试剂, 2011, 33(3): 199-202,206 |
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| 作者姓名： | 林森 邓检阳 江玉春 邓瑞红 揭克敏 高明 |
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| 作者单位： | 1. 南昌大学化学系,江西,南昌,330031
2. 南昌大学医学院,江西,南昌,330031 |
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| 基金项目： | 国家自然科学基金资助项目，江西省自然科学基金资助项目 |
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| 摘 要： | 采用含硅二烃基锡氧化物和相应的吡啶甲酸,合成了7个新的含硅二烃基锡配合物--标题化合物;通过IR、1HNMR、13CNMR和元素分析对它们的结构进行表征.生物活性测定的初步结果表明,目标化合物环已基(三甲基硅基亚甲基)锡二(2-吡啶羧酸酯)Cy(Me3SiCH2)Sn(OCOC5H4N-o)2对肺癌细胞A549和肠癌细...
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| 关 键 词： | 含硅有机锡化合物 吡啶羧酸酯 合成 结构 抗癌活性 |
Synthesis and structure of diorganotin pridinecarboxylates containing silicon |
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| LIN Sen,DENG Jian-yang,JIANG Yu-chun,DENG Rui-hong,JIE Ke-min,GAO Ming. Synthesis and structure of diorganotin pridinecarboxylates containing silicon[J]. Chemical Reagents, 2011, 33(3): 199-202,206 |
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| Authors: | LIN Sen DENG Jian-yang JIANG Yu-chun DENG Rui-hong JIE Ke-min GAO Ming |
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| Affiliation: | LIN Sen~a,DENG Jian-yang~a,JIANG Yu-chun~a,DENG Rui-hong~a,JIE Ke-min~b,GAO Ming~a(Nanchang University,a.Department of Chemistry,b.Medical College,Nanchang 330031,China) |
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| Abstract: | Seven diorganotin pridinecarboxylates containing silicon were synthesized by the reaction of diorganotin oxides with pridinecarboxylic acids.The structures were affirme via IR,1HNMR,13CNMR,elemental analysis.The preliminary bioassay tests showed that the compound Cy(Me3SiCH2)Sn-(OCOC5H4N-o)2 exhibited a good antitumour activity in vitro against lung tumour cells A549 and colorectal tumour cell SW480. |
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| Keywords: | diorganotin containing silicon pridinecarboxylate synthesis structure antitumour activity |
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