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Effects of <Emphasis Type="Italic">cheonggukjang</Emphasis> containing arrowroot isoflavones on bone metabolism in ovariectomized rats
Authors:Lee Myung-Ye  Chang Kyung-Ho
Affiliation:(1) Department of Animal Science, National Chiayi University, Chiayi, Taiwan;(2) Department of Veterinary Medicine, National Chiayi University, Chiayi, Taiwan;(3) Department of Food Science, National Chiayi University, Chiayi, Taiwan
Abstract:The effects of dietary supplementation with cheonggukjang containing arrowroot isoflavones (AIC) on bone mineral density and bone metabolism were investigated in 6-week old ovariectomized Sprague-Dawley rats divided into 4 groups: sham (sham-operation and basal diet), OVX (ovariectomy and basal diet), OVX+C (ovariectomy and basal diet with 5% cheonggukjang), and OVX+AIC (ovariectomy and basal diet with 5% AIC). Eight weeks following ovariectomy, body weight gain, and serum alkaline phosphatase activities were significantly reduced in OVX+C and OVX+AIC. Serum osteocalcin levels were significantly lower in OVX+AIC. Although urinary calcium, phosphorus, and creatinine levels increased after ovariectomy, they decreased in OVX+AIC. Bone mineral densities decreased in OVX but significantly enhanced after C and AIC supplementation. Bone mineral content did not significantly differ between OVX+AIC and sham. Thus, these results suggest that AIC may prevent bone loss in OVX rats.
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