Ultrasensitive colorimetric DNA detection using a combination of rolling circle amplification and nicking endonuclease-assisted nanoparticle amplification (NEANA) |
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Authors: | Xu Wei Xie Xiaoji Li Dawei Yang Zhaoqi Li Tianhu Liu Xiaogang |
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Affiliation: | Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543. |
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Abstract: | A combination of rolling circle amplification and nicking endonuclease-assisted nanoparticle amplification (NEANA) is used for the rapid, colorimetric detection of DNA. The integration of rolling circle amplification into the NEANA approach allows for detection of oligonucleotides with arbitrary sequences at ultralow concentrations. |
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Keywords: | colorimetric detection gold nanoparticles DNA nicking endonuclease rolling circle amplification |
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