Invited review: Anti-adhesive properties of bovine oligosaccharides and bovine milk fat globule membrane-associated glycoconjugates against bacterial food enteropathogens |
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| Authors: | T Douëllou MC Montel D Thevenot Sergentet |
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| Affiliation: | 2. Université de Lyon, Bacterial Opportunistic Pathogens and Environment Research Group, UMR5557 Ecologie Microbienne Lyon, Université Lyon 1, CNRS (National Center of Scientific Research), VetAgro Sup, 69280 Marcy-l''Etoile, France |
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| Abstract: | The prevalence of the main raw milk and raw milk–derived dairy product enteropathogens (Campylobacter, Shiga toxin-producing Escherichia coli, Listeria, and Salmonella) is higher than the number of epidemiological cases related to ingesting these foodstuffs. Bovine milk oligosaccharides and milk fat globule membrane (MFGM)-linked glycoconjugates interact with foodborne enteropathogens to inhibit their adhesion to intestinal cells and tissues. This review examines the main mechanisms and strategies used by enteropathogens to adhere to their target, details the anti-adhesive properties of MFGM against enteropathogens and enterotoxins, assesses the integrity of bacteria–MFGM complexes during dairy product manufacture and digestion, and discusses the potential for using these macromolecules and glycoconjugates in foods for public health. |
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| Keywords: | bacterial enteropathogen adhesion inhibition milk fat globule glycoconjugate oligosaccharides |
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