Unveiling the Mode of Action of Two Antibacterial Tanshinone Derivatives |
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| Authors: | Dongdong Wang Wuxia Zhang Tingting Wang Na Li Haibo Mu Jiwen Zhang Jinyou Duan |
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| Affiliation: | College of Science, Northwest A&F University, Yangling 712100, Shaanxi, China; E-Mails: (D.W.); (W.Z.); (T.W.); (N.L.); (H.M.); (J.Z.) |
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| Abstract: | In this study, 2-(N-pyrrolidine-alkyl) tanshinones bearing pyrrolidine groups were synthesized and the antibacterial mechanism was explored. These derivatives selectively elicited antibacterial activity against Gram-positive bacteria. Moreover, their antibacterial activities were time-, concentration-dependent and persistent. It appeared that Fenton-mediated hydroxyl radicals were involved, and the disruption of cell membranes was observed. This study indicates that 2-(N-pyrrolidine-alkyl) tanshinones might be potential candidates as antibacterial agents. |
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| Keywords: | tanshinone pyrrolidine antibacterial reactive oxygen species (ROS) membrane |
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