Genetic Polymorphisms of Glutathione-Related Enzymes (GSTM1, GSTT1, and GSTP1) and Schizophrenia Risk: A Meta-Analysis |
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| Authors: | Su Kang Kim Sang Wook Kang Joo-Ho Chung Hae Jeong Park Kyu Bong Cho Min-Su Park |
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| Affiliation: | 1.Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul 130-701, Korea; E-Mails: (S.K.K.); (S.W.K.); (J.-H.C.); (H.J.P.);2.Department of Biomedical Laboratory Science, College of Health Sciences, Shinhan University, Gyeonggi 480-701, Korea; E-Mail: ;3.Department of Surgery, School of Medicine, Kyung Hee University, Seoul 130-702, Korea |
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| Abstract: | The association between polymorphisms of glutathione-related enzyme (GST) genes and the risk of schizophrenia has been investigated in many published studies. However, their results were inconclusive. Therefore, we performed a meta-analysis to explore the association between the GSTM1, GSTT1, and GSTP1 polymorphisms and the risk of schizophrenia. Twelve case-control studies were included in this meta-analysis. The odds ratio (OR) and 95% confidence interval (95% CI) were used to investigate the strength of the association. Our meta-analysis results revealed that GSTM1, GSTT1, and GSTP1 polymorphisms were not related to risk of schizophrenia (p > 0.05 in each model). Further analyses based on ethnicity, GSTM polymorphism showed weak association with schizophrenia in East Asian population (OR = 1.314, 95% CI = 1.025–1.684, p = 0.031). In conclusion, our meta-analysis indicated the GSTM1 polymorphism may be the only genetic risk factor for schizophrenia in East Asian population. However, more meta-analysis with a larger sample size were needed to provide more precise evidence. |
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| Keywords: | glutathione S-transferase enzymes polymorphism schizophrenia meta-analysis |
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