Selective expression of one c-myc allele in two human myeloma cell lines |
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Authors: | WM Kuehl LA Brents M Chesi PL Bergsagel |
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Affiliation: | National Cancer Institute-Navy Medical Oncology Branch, NIH, Bethesda, Maryland 20889-5105, USA. Michael_Kuehl@nih.gov |
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Abstract: | Chromosomal translocations or DNA rearrangements affecting c-myc occur in almost all murine plasmacytoma and human Burkitt's lymphoma tumors and are associated with a high incidence of exon 2 missense mutations and selective expression of the affected allele. Screening nine multiple myeloma cell lines, we identified no exon 2 missense mutations but did identify two lines with single, silent mutations in exon 1 and exon 2, respectively. Each of these informative multiple myeloma cell lines selectively expresses only one c-myc allele despite the apparent absence of chromosomal translocations or DNA rearrangements affecting c-myc. |
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