阿霉素在羧基化纳米金刚石表面的负载与释放性能研究

利用高温氧化法实现纳米金刚石表面羧基化,以提高其对阿霉素药物的负载率。通过考查高温氧化条件、药物浓度、溶液pH值等因素对其载药效果的影响规律,得出最佳载药条件,制备了负载量为425 μg/mg的纳米金刚石-阿霉素体系。探索了不同pH环境下该载药体系的药物释放规律,结果表明,羧基化纳米金刚石负载阿霉素后,可高效释药,最高释放率可达91%,说明纳米金刚石在改善药效发挥、降低药量、减少毒副作用等方面具有巨大潜力。

Loading of Doxorubicin on Surface-Carboxylated Nanodiamond and Its Release Performance

High temperature oxidation approach was introduced to obtain a surface-carboxylated nanodiamond (ND), so as to benefit the loading of doxorubicin (DOX) thereon. The influences of oxidation parameters, drug concentration and solution pH value on drug loading behavior were investigated. ND-DOX system with a loading capacity of 425 μg/mg was prepared under the optimal conditions. Subsequently, the release performance of the loaded DOX under different pH conditions was studied. It is shown that carboxylated ND loaded with DOX can lead to a high-efficient drug release with the highest release rate attaining 91%, indicating that the ND carrier may have an application potential in improving drug efficacy, reducing drug dosage and minimizing drug toxicity.