Effects of the atypical antipsychotics amperozide and clozapine on behavior maintained by food, cocaine, or alfentanil in rhesus monkeys. |
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Authors: | Winger Gail; Butelman Eduardo R |
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Abstract: | Amperozide and clozapine are antipsychotic drugs that act primarily as antagonists at 5-hydroxytryptamine (5-HT?) sites. In different groups of rhesus monkeys (Macaca mulatta) receiving food, cocaine, or alfentanil as a consequence of responding on FR 30 schedules, the antipsychotic drugs produced dose-dependent decreases in behavior. Amperozide was more potent in suppressing food or cocaine-maintained responding than in suppressing alfentanil-maintained responding. Clozapine was nearly equally potent in suppressing behavior maintained by the different reinforcers. Neither drug showed a specificity of effect that suggests use in the treatment of cocaine or opioid abuse. (PsycINFO Database Record (c) 2010 APA, all rights reserved) |
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