多光谱光声层析技术在肿瘤学中的应用进展

多光谱光声层析技术是一种新兴的光声成像技术，兼具光声断层扫描和多光谱成像的优点。该成像技术需要利用内源性和外源性光声成像对比剂进行成像。成像时，激光发射器发射多个波长的激光束照射组织，组织发生热弹性膨胀并产生超声波，将超声换能器接收的光声信号进行后处理，分解光谱信息并重建图像。目前，多光谱光声层析技术已广泛用于多种肿瘤的研究。文章着重介绍光声成像对比剂和多光谱光声层析技术的发展近况以及在临床转化中取得的研究进展。

Advances in the application of multispectral optoacoustic tomography in oncology

Multispectral optoacoustic tomography is an emerging photoacoustic imaging technology, which combines the virtues of both photoacoustic tomography and multispectral imaging. This imaging technology requires the use of photoacoustic imaging contrast agents, which can be divided into endogenous and exogenous categories. During imaging, the laser emitter emits laser beams of multiple wavelengths to irradiate the tissue, which produces thermoelastic expansion and ultrasonic waves. The image post-processing algorithm processes the photoacoustic signals received by ultrasonic transducers, decomposes spectral information and reconstructs the image. At present, multispectral photoacoustic tomography has been widely used to study several kinds of tumors. This review focuses on the recent advances and clinical translation of photoacoustic imaging contrast agents and multispectral photoacoustic tomography.