Targeted blue nanoparticles as photoacoustic contrast agent for brain tumor delineation |
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Authors: | Aniruddha Ray Xueding Wang Yong-Eun Koo Lee Hoe Jin Hah Gwangseong Kim Thomas Chen Daniel A Orringer Oren Sagher Xiaojun Liu Raoul Kopelman |
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Affiliation: | 1. Biophysics, University of Michigan, Ann Arbor, MI, 48109, USA 2. Department of Radiology, University of Michigan, Ann Arbor, MI, 48109, USA 3. Department of Chemistry, University of Michigan, Ann Arbor, MI, 48109, USA 4. Department of Neurosurgery, University of Michigan, Ann Arbor, MI, 48109, USA 5. Institute of Acoustics, Nanjing University, Nanjing, 210093, China
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Abstract: | Distinguishing a tumor from non-neoplastic tissue is a challenging task during cancer surgery. Several attempts have been
made to use visible or fluorescent agents to aid in the visualization of a tumor during surgery. We describe a novel method
to delineate brain tumors, using a highly sensitive photoacoustic imaging technique that is enhanced by tumor-targeting blue
nanoparticles serving as a contrast agent. Experiments on phantoms and on rat brains, ex vivo, demonstrate the high sensitivity of photoacoustic imaging in delineating tumors containing contrast agent at a concentration
much lower than needed for visualization by the naked eye. The limit of detection of the system for the nanoparticles is about
0.77 μg/mL in water (equivalent to 0.84 μmol/L Coomassie Blue dye). The present exploratory study suggests that photoacoustic
imaging, when used with strongly optical absorbing contrast agents, could facilitate cancer surgery intraoperatively by revealing
the distribution and extent of the tumor.
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Keywords: | Brain tumor surgery targeted nanoparticles F3 peptide Coomassie Blue dye photoacoustic imaging |
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