Gamma radiation-induced differentiation on human neuroblastoma cells in culture |
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| Authors: | P Rocchi AM Ferreri G Simone D Granchi P Nanni A Frau P Paolucci G Paolucci |
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| Affiliation: | Istituto di Cancerologia, Università di Bologna, Italy. |
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| Abstract: | We have studied the effect of gamma radiation on differentiation in neuroblastoma cell lines AF8 and SJ-N-KP. Growth inhibition and morphological and biochemical differentiation have been examined following radiation exposure to 1-10 Gy. Gamma radiation induced marked growth inhibition and morphological differentiation in a dose-and time-dependent manner in both cell lines, and induced biochemical differentiation in AF8 cells. |
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