| 3-甲基-2-硝基苯酚的合成工艺改进 |
| |
| 引用本文： | 王文智,张丽娟,赵湘萌,王展,宋宏锐.3-甲基-2-硝基苯酚的合成工艺改进[J].精细化工中间体,2011,41(6):26-27,40. |
| |
| 作者姓名： | 王文智 张丽娟 赵湘萌 王展 宋宏锐 |
| |
| 作者单位： | 沈阳药科大学制药工程学院,辽宁沈阳,110016 |
| |
| 摘 要： | 以间甲基苯酚为原料,通过磺化、硝化、水解反应,合成3-甲基-2-硝基苯酚。考察了反应物料配比、反应时间、反应温度对收率的影响。收率为98%。目标化合物的结构经1H NMR确证。改进后的工艺降低了合成成本,简单可行,适合工业化生产。
|
| 关 键 词： | 3-甲基-2-硝基苯酚 合成 工艺改进 |
Improved Synthesis of 3-Methyl-2-nitrophenol |
| |
| WANG Wen-zhi
,
ZHANG Li-juan
,
ZHAO Xiang-meng
,
WANG Zhan
,
SONG Hong-rui.Improved Synthesis of 3-Methyl-2-nitrophenol[J].Fine Chemical Intermediates,2011,41(6):26-27,40. |
| |
| Authors: | WANG Wen-zhi ZHANG Li-juan ZHAO Xiang-meng WANG Zhan SONG Hong-rui |
| |
| Affiliation: | (School of Pharmaceutical Engineering,Shenyang Pharmaceutical University,Shenyang 110016,China) |
| |
| Abstract: | 3-Methyl-2-nitrophenol was prepared from 3-methyl phenol via sulfonation,nitration and hydrolysis in an overall yield of 98%.The influence factors on the yield of the target product were investigated.The structure was characterized with 1H NMR.This improved process can simplify the scale manipulation and reduce the cost. |
| |
| Keywords: | 3-methyl-2-nitrophenol synthesis process improvement |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
