Interaction of Salmonella typhi strains with cultured human monocyte-derived macrophages |
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| Authors: | DR Sizemore EA Elsinghorst LC Eck AA Branstrom DL Hoover RL Warren FA Rubin |
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| Affiliation: | Department of Bacterial Diseases, Walter Reed Army Institute of Research, Washington, D.C. 20307-5100, USA. |
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| Abstract: | Human monocyte-derived macrophages (MDM) provided this laboratory with a tool to develop a primary-cell assay for evaluating the relative virulence of newly constructed Salmonella typhi carrier strains. In this study, the interaction with and survival within MDM were compared for delta aroA143-attenuated strains, wild-type virulent strains, and the current oral-vaccine strain, Ty21a. |
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