红霉素分子印迹聚合物纳米微球的制备及其吸附特性

以红霉素为模板分子、甲基丙烯酸为功能单体、乙二醇二甲基丙烯酸酯为交联剂，采用沉淀聚合法制备了粒径均一的红霉素纳米分子印迹聚合物微球，优化了分子印迹聚合物的合成条件，确定了模板分子与功能单体的最佳摩尔比为1:3，对其进行了表征. 结果表明，所制聚合物对红霉素的实际最大吸附量可达202.12 mg/g，吸附约200 min达到平衡，对红霉素具有良好的选择性吸附能力.

Preparation of Molecularly Imprinted Nanoparticles for Erythromycin and Their Adsorption Characteristics

Uniform molecularly imprinted polymer (MIP) nanoparticles for erythromycin (EM) were prepared by precipitation polymerization using EM as template molecule, methacrylic acid (MAA) as functional monomer and ethylene glycol dimethacrylate (EGDMA) as cross-linker. The synthesis conditions of MIP nanoparticles were optimized and the optimum molar ratio of template molecule to functional monomer was obtained as 1:3. The MIP nanoparticles were characterized. Moreover, the actual maximum apparent adsorption capacity of MIP nanoparticles obtained from the binding experiments was 202.12 mg/g, the adsorption kinetics of MIP nanoparticles showed that the adsorption of MIP nanoparticles in adsorption solution would be equilibrium after 200 min. The MIP nanoparticles for EM possessed highly selective adsorption capacity.