Simple Evaluation Method of Intrinsic Diffusivity for Membrane-Moderated Controlled Release |
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Authors: | Kakuji Tojo Ying Sun Musa Ghannam Yie W. Chien |
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Affiliation: | a Controlled Drug-Delivery Research Center Rutgers University, College of Pharmacy Piscataway, New Jersey |
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Abstract: | The effect of diffusion boundary layers in an in vitro membrane permeation system on the membrane diffusivity of drugs was investigated based on the three-layer model. A simple method for evaluating the intrinsic diffusivity through the membrane was developed and the intrinsic diffusivity of progesterone and testosterone through a silicone membrane were determined using this approach. |
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