Modeling and simulation of osteoporosis and fracture of trabecular bone by meshless method |
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| Affiliation: | 1. School of Engineering and Applied Science, The George Washington University, Washington, DC 20052, USA;2. Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, FL 3261l, USA;3. Turner-Fairbank Highway Research Center, Federal Highway Administration, US Department of Transportation, McLean, VA 22101, USA;1. Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Republic of Korea;2. School of Medicine, Pusan National University, Busan 49241, Republic of Korea;3. Department of Naval Architecture and Ocean Engineering, Pusan National University, Busan 46241, Republic of Korea;4. Department of Biological Sciences, Pusan National University, Busan 46241, Republic of Korea;5. Department of Orthopaedic Surgery, Medical Research Institute, Pusan National University Hospital, Busan 49241, Republic of Korea;1. Institute of Legal Medicine, Ludwig Maximilian University of Munich, Munich, Germany;2. Biomechanics Laboratories, Department of Engineering and Applied Science, Cranfield University, Cranfield, United Kingdom;3. Faculty of Industrial Technologies, Hochschule Furtwangen University, Tuttlingen, Germany;1. Division of Field Engineering for the Environment, Faculty of Engineering, Hokkaido University, Kita-13 Nishi-8, Kita-ku, Sapporo, Japan;2. Division of Field Engineering for the Environment, Graduate School of Engineering, Hokkaido University, Kita-13 Nishi-8, Kita-ku, Sapporo, Japan;1. Institute of Mechanical Engineering and Industrial Management, Rua Dr.Roberto Frias, S/N, 4200-465 Porto - Portugal;2. Faculty of Engineering of the University of Porto, Rua Dr.Roberto Frias, S/N, 4200-465 Porto - Portugal |
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| Abstract: | Osteoporosis is a skeletal disease characterized by a decrease in bone strength as a result of a decrease of bone mass and a deterioration of bone microstructure. In this work, the imaging data of a CT scanned human femoral neck trabecular bone is directly converted into a meshless model. A model is developed to analyze osteoporosis process. A fracture criterion and the corresponding post-failure are proposed for trabecular bone. The fracture process is modeled and simulated. The simulations show that the fracture stress is not a monotonically decreasing function in the process of fracture, and the microstructure of trabecular bone has a positive effect in preventing progressive failure. The approach in this work may be used to understand the osteoporosis-related fracture and the bone density–strength relationship, and to serve as a way for prognosis of osteoporosis. |
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