| 盐酸帕洛诺司琼中间体的合成 |
| |
| 引用本文： | 王平,陶春妙.盐酸帕洛诺司琼中间体的合成[J].浙江化工,2009,40(9):13-15. |
| |
| 作者姓名： | 王平 陶春妙 |
| |
| 作者单位： | 浙江工业大学药学院,浙江,杭州,310014 |
| |
| 摘 要： | 研究了双（三氯甲基）碳酸酯替代传统氯代试剂合成盐酸帕洛诺司琼中间体的新工艺路线。以1-萘甲酸为起始原料,经还原,氯化,酰胺化,手性拆分,得到盐酸帕洛诺司琼中间体,该工艺具有生产安全,环境友好,操作简单等优点,反应总收率为26.8%。
|
| 关 键 词： | 盐酸帕洛诺司琼 双(三氯甲基)碳酸酯 合成 |
Synthesis of the Chemical Intermediate of Palonosetron Hydrochloride |
| |
| WANG Ping,TAO Chun-miao.Synthesis of the Chemical Intermediate of Palonosetron Hydrochloride[J].Zhejiang Chemical Industry,2009,40(9):13-15. |
| |
| Authors: | WANG Ping TAO Chun-miao |
| |
| Affiliation: | (College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, 310014, China) |
| |
| Abstract: | The bis（trichloromethyl）carbonate replaced the traditional chlorination reagent to synthesize of the chemical intermediate of palonosetron hydrochloride. The chemical intermediate of palonosetron hydrochloride was synthesized from α-naphthoic acid via reduction, chlorination, amidation and chiral resolution. The advantages of this procedure are simple, safe and environmentally friendly. The total yield was 26.8%。 |
| |
| Keywords: | palonosetron hydrochloride bis-trichloromethyl carbonate synthesis |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
