| 半胱胺改性叶酸衍生物的制备及其性能研究 |
| |
| 引用本文： | 包金远,刘继宪,唐建国,王瑶,徐慧芬,于亚楠.半胱胺改性叶酸衍生物的制备及其性能研究[J].应用化工,2010,39(4):507-509. |
| |
| 作者姓名： | 包金远 刘继宪 唐建国 王瑶 徐慧芬 于亚楠 |
| |
| 作者单位： | 1. 青岛大学,杂化材料研究所,山东,青岛,266071
2. 青岛大学,杂化材料研究所,山东,青岛,266071;青岛大学,化学化工与环境学院,山东,青岛,266071 |
| |
| 基金项目： | 国家重点基础研究发展规划(973计划)，山东省自然科学基金 |
| |
| 摘 要： | 在N,N-二环己基碳酰亚胺(DCC)和N-羟基琥珀酰亚胺(NHS)共同催化下制备出半胱胺改性叶酸衍生物,在pH=8的稀氨水溶液中,对纳米金和叶酸衍生物进行偶联。结果表明,叶酸的羧基与半胱胺的巯基发生了反应,叶酸衍生物具有荧光性能,并与纳米金粒子有吸附作用,在叶酸靶向肿瘤诊断治疗方面具有潜在的应用价值。
|
| 关 键 词： | 叶酸衍生物 半胱胺 纳米金 靶向 |
Study on preparation and properties of folic acid modified by cysteamine derivatives |
| |
| BAO Jin-yuan,LIU Ji-xian,TANG Jian-guo,WANG Yao,XU Hui-fen,YU Ya-nan.Study on preparation and properties of folic acid modified by cysteamine derivatives[J].Applied chemical industry,2010,39(4):507-509. |
| |
| Authors: | BAO Jin-yuan LIU Ji-xian TANG Jian-guo WANG Yao XU Hui-fen YU Ya-nan |
| |
| Abstract: | Folic acid modified by cysteamine derivatives was synthesized through N,N-dicyclohexylcarbon-imide(DCC)and N-hydroxysuccinimide(NHS) as co-catalyst.The folic acid derivative was conjugated with gold nanoparticles in dilute ammonia solution.The results showed that folic acid carboxyl and the —SH of cysteamine had reacted successfully.The products had fluorescent properties.Folic acid derivatives adsorbed the nano-Au particles,which might have potential application value in folic acid targeted cancer diagnosis and treatment areas. |
| |
| Keywords: | folic acid derivatives cysteamine nano-Au target |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
