Investigation on cyclic guanidine derivatives. Part III. Synthesis and properties of 2-piperidino and 2-homopiperidino-tetrahydropyrimidine-4,6-dione derivatives

Two cases of intoxication by diphenoxylate, inespecific antidiarrheal, depressor of the intestinal motility, are presented. Diphenoxylate is chemically related with meperidine. One case was caused by hipersensitivity and the other one by overdose. Both had a favourable outcome. Existent bibliography was reviewed and clinical signs of this intoxication pointed-out. It is suggested that diphenoxylate should not be prescribed to children under thirty months.