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HIV-1: is Nef a PAK animal? |
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| Authors: | BR Cullen |
| Affiliation: | Howard Hughes Medical Institute, Durham, North Carolina, USA. |
| Abstract: | HIV-1 Nef is clearly essential for efficient viral replication in vivo, but it has been difficult to determine why. Recent evidence that Nef specifically activates a PAK-dependent signalling cascade may be the first step in defining the mechanism of action of this enigmatic viral protein. |
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