毛细管气相色谱法测定美西林中3种残留有机溶剂

建立了美西林中3种残留有机溶剂（甲醇、乙腈、丙酮）的分离测定方法。采用HP-1（60m×0．53μm×5．00μm）毛细管柱，以氮气为载气，FID检测器，程序升温，柱温为30℃，保持6min，以8℃／min的速度升温至60℃，进样口温度200℃，检测器温度250℃，分流直接进样，外标法计算残留溶剂的含量。结果显示，甲醇、乙腈、丙酮的峰面积对浓度均具有良好的线性关系，精密度相对标准偏差（RSD）均≤2．0％，平均回收率在98．8％～99．4％。本法简单、准确、灵敏度高，适用于美西林中3种残留的有机溶剂同时测定。

Determination of three residual organic solvents in Mecillinam by CGC

For the determination of three residual organic solvents （methanol, acetonitrile, acetone） in Mecillinam, a capillary gas chromatography （CGC） method was established. The residual organic solvents in Mecilliham were determinated by directed injection on a HP-1 capillary column （60m× 0.53μm× 5.0μm） and at a FID detector. The carrier gas was nitrogen gas. The injector temperature was 200℃ and the detector temperature was 250℃. The column temperature program was initial temperature 30℃ （hold 6min）, with the increase rate of 8℃/min to 160℃. The content of residual solvents was calculated by external standard method. The result indi- cated that the calibration curves of methanol, acetonitrile and acetone showed good linearity, the relative standard deviation （RSD） of precision was all less than 2.0% ; the average recoveries were between 98.8%-99.4%. The method is simple, accurate, sensitive, and can be used for detection of three residual solvents in Mecillinam simultaneously.