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| 混酸法改进美沙拉嗪的合成 | |
| 引用本文： | 谭载友,刘天穗,邹更新,吕竹芬,徐晓彬,薛莲芳,林彬. 混酸法改进美沙拉嗪的合成[J]. 广州化工, 2003, 31(1): 37-38 |
| 作者姓名： | 谭载友 刘天穗 邹更新 吕竹芬 徐晓彬 薛莲芳 林彬 |
| 作者单位： | 1. 广东药学院药物研究所,广州,510224 2. 广州大学,510091 3. 广东省科技学校,510000 |
| 基金项目： | 广东省科技厅重点攻关项目 |
| 摘 要： | 以硝酸和浓硫酸混合硝化水杨酸，然后还原合成美沙拉嗪，总产率为39.2%。该法可用于工业规模生产提高产品纯度。 |
| 关 键 词： | 混酸法 改进 美沙拉嗪 合成 药物 硝化 还原 |
Improved Synthesis of Mesalazine with the Mixture of Nitric Acid and Sulfuric Acid |
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| Abstract: | This improved synthesis of mesalazine stars from salicylic acid, which is converted to mesalazine in two steps of nitrification and reduction in 39.2 % overall yield by treatment of key the mixture of nitric acid and sulfuric acid. The synthesis is suitable for large scale production and have been employed to produce kilograms supplies of mesalazine in high purity. |
| Keywords: | mesalazine synthesis mixture of nitric acid and sulfuric acid nitrification reduction |
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