Spray-dried hydroxyapatite-5-Fluorouracil granules as a chemotherapeutic delivery system |
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| Authors: | C Santos CF Rovath R-P Franke MM Almeida MEV Costa |
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| Affiliation: | 1. Department of Ceramic and Glass Engineering, Lugar de Santiago, CICECO, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal;2. Institute for Biological Interfaces, Forschungszentrum Karlsruhe GmbH, 76344 Eggenstein-Leopoldshafen Karlsruhe, Germany;3. Department of Biomaterials, University of Ulm, 89081 Ulm, Germany |
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| Abstract: | This study describes the preparation and characterization of hydroxyapatite-5-Fluorouracil (5FU) granules, which are intended to be used as chemotherapeutic delivery matrices and bone regeneration templates. Suspensions of hydroxyapatite (Hap) nanoparticles in 5FU solution are spray dried as micro sized granules having donut type shape. Several spray drying temperatures are studied 80 °C being the optimized condition for obtaining granules composed by Hap and 5FU without secondary phases. The produced granules at 80 °C reveal a fast releasing rate of 5FU when soaked in buffer phosphate solution maintained at physiological temperature (37 °C), thereby indicating the potential application of the produced Hap matrices for drug delivery systems (DDSs). |
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| Keywords: | [A] Spray drying [A] Drug delivery [D] Hydroxyapatite [D] 5-Fluorouracil |
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