99mTc(CO)3-PNP5新型配合物的初步研究 |
| |
引用本文: | 楚进锋.99mTc(CO)3-PNP5新型配合物的初步研究[J].同位素,2007,20(3):154-159. |
| |
作者姓名: | 楚进锋 |
| |
作者单位: | 北京化工大学理学院 |
| |
摘 要: | 采用两步法成功制备了99mTc(CO)3-PNP5新型配合物,优化了标记条件,标记率大于90%,并对其生物性能进行初步研究。理化性质研究表明:99mTc(CO)3-PNP5是一种体外稳定性好、具有一定脂溶性的阳离子配合物。小鼠生物分布研究表明:99mTc(CO)3-PNP5在心肌中有一定的初始摄取和较好的滞留;血和肺的初始摄取较低,清除较快;肝中的初始摄取高,而清除迅速。而引入Tween-80后,配合物在小鼠中的心肌初始摄取较高,滞留较好;肝中初始摄取较低且清除很快,心/肝比高,明显改善了配合物99mTc(CO)3-PNP5的生物性能。
|
关 键 词: | 99mTc(CO)3-PNP5 生物分布 心肌灌注显像剂 |
收稿时间: | 2006-06-15 |
Preliminary Study on the 99mTc(CO)3-PNP5 Complex |
| |
Abstract: | The objective of this study is to synthesize 99mTc(CO)3-PNP5 through ligand exchange reaction and to study its biological characters. Labelling conditions of 99mTc(CO)3-PNP5 were optimized and its labelling yield was over 90% determined by TLC. The results of partition coefficient, charge character and stability studies indicated that 99mTc(CO)3-PNP5 is a lipophilic cation with good stability. Biological properties of 99mTc(CO)3-PNP5 and 99mTc(CO)3-PNP5(T) were valued contrastively in mice. The results showed that 99mTc(CO)3-PNP5(T) had higher myocardial uptake, lower liver uptake, and better heart-to-liver ratio. This indicated that the biological properties of 99mTc(CO)3-PNP5 were improved obviously by adding Tween-80. |
| |
Keywords: | 99mTc(CO)3-PNP5 biodistribution myocardial perfusion imaging agent |
|
| 点击此处可从《同位素》浏览原始摘要信息 |
|
点击此处可从《同位素》下载全文 |