新型脑受体显像剂99mTc- Memantine的制备及药盒化 |
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引用本文: | 张建康. 新型脑受体显像剂99mTc- Memantine的制备及药盒化[J]. 同位素, 2008, 21(4): 209 |
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作者姓名: | 张建康 |
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作者单位: | 江苏省原子医学研究所 |
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摘 要: | 合成了 N-[2-(N-(2-巯基乙基) )氨基甲酰甲基]-N-(2-巯基乙基)- 3,5-二甲基金刚烷胺基乙酰胺(II N2S2- Memantine),对其进行99mTc标记。用氟化亚锡作还原剂,与高锝酸钠盐溶液反应,生成的新型脑受体显像剂I 99mTc(V)- Memantine,优化标记条件,进一步研制了无菌99mTc(V)- Memantine一步法冻干药盒。薄层色谱(TLC)对标记物进行质控,检测标记物的体外稳定性。结果显示,标记物的放化纯度〉95%,稳定性好,有望成为一种新型脑受体显像剂。
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关 键 词: | 锝标记 美金刚胺 双氨基乙硫醇类 脑受体 显像剂 |
收稿时间: | 2008-07-11 |
Preparation of 99mTc-Memantine as a Novel Brain Receptor Imaging Agent and Its Lyophilized Kit |
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Abstract: | The precursor of compound II N2S2-Memantine was synthesized. N2S2-Memantine was labeled with 99mTc by using stannous fluoride as reducing agent,and the labeling conditions of I 99mTc(V)- Memantine were optimized, and lyophilized kit of 99mTc(V)- Memantine was also developed. The labeling yields in excess of 90% and radiochemical purity more than 95% by the TLC analyses. The product was good stability in room temperature. 99mTc(V)- Memantine would be a potential brain receptor imaging agent which would need more research work. |
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Keywords: | 99mTc labeling memantine bis(aminoethanethiol) analog brain receptor imaging agent |
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