模拟体液中Na/Mg/F共掺杂羟基磷灰石的制备和表征

采用化学沉淀法，在模拟体液环境中制备了Na、Mg、F三元素共掺杂的羟基磷灰石( HA)粉体，利用XRD、FT-IR、SEM、EDS等技术对其物相结构、微观形貌、化学组成和热稳定性进行了分析和表征。结果表明：Na/Mg/F对HA进行掺杂引起HA晶格发生畸变。 F元素的掺杂量对HA的形貌具有一定的影响；随着F掺杂量的增加，球形的HA颗粒逐渐转变成棒状结构。 F/P=0.25时，可以制得小而均匀的HA颗粒。抑菌环实验表明Na/Mg/F共掺杂HA对金黄色葡萄球菌的生长具有一定的抑制作用。 F/P=0.25时，抗菌性最强。煅烧温度在1000℃时HA的物相未发生变化，说明样品具有良好的热稳定性。

Preparation and Characterization of Na/Mg/F Co-doped Hydroxyapatite in Simulated Body Fluids

Na/Mg/F three elements co-doping hydroxyapatite ( HA) powders were prepared by chemical precipitation method in simulated body fluids environment. The phase, structure, micromorphology, chemical composition and thermal stability of the obtained powders were analyzed and characterized by XRD, FT-IR, SEM and EDS. The results show that Na/Mg/F co-doping cause the lattice distortions of HA and the doping amount of F element has some influences on the morphology of HA. With the increase of the doping amount of F element, spherical HA particles gradually transformed into the rod-like structure. When the ratio of F/P was 0. 25, HA particles with small and uniform can be obtained. The bacteriostatic ring test indicated that the Na/Mg/F co-doping HA had an inhibitory effect on growth of Staphylococcus aureus. While the ratio of F/P was 0. 25, HA powders possessed the best antibacterial activity. The phase of HA calcined at 1000 ℃ did not change showed its good thermal stability.