Epoxides as products of lipid autoxidation in rat lungs |
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Authors: | Alex Sevanian James F Mead Robert A Stein |
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Affiliation: | (1) Laboratory of Nuclear Medicine and Radiation Biology, University of California, 90024 Los Angeles, CA;(2) Department of Biological Chemistry, UCLA School of Medicine, 90024 Los Angeles, CA |
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Abstract: | The nature and content of lipid epoxides in rat lung were examined in air-breathing control rats and those exposed to nitrogen
dioxide. Exposure to 6.5 ppm NO2 for 24 hr resulted in significantly greater epoxide content in a number of lipid classes. It is proposed that lipid autoxidation
in lung tissues may contribute to the levels of epoxide-containing lipids. Furthermore, the processes involved in epoxide
formation may be predicted from autoxidation studies utilizing a system of unsaturated fatty acid monolayers on silica gel
which serves as a model for biomembranes. The findings indicate that exposure to oxidizing gases can lead to an accumulation
of lipid epoxides in both lung parenchymal tissue and on the alveolar surface. |
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