Damage occurs early in systemic vasculitis and is an index of outcome

The use of products containing PCB in buildings resulted in indoor air contaminations. The search for appropriate measures is hampered by several different uncertainties in the regulatory toxicological process. These refer to problems in exposure assessment including measurement approaches, the toxicological evaluation of health risks including the derivation of a tolerable intake and the use of TCDD toxicity equivalency factors and finally the legal consequences of health risk evaluation. Since no consensus on these aspects has been achieved, the regulatory consequences vary considerably from one German state government to the other. FAO/WHO have not been able to arrive at a satisfactory supranational recommendation of a tolerable intake for PCB.