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| 高良姜根茎的化学成分及抗口腔菌活性测定 | |
| 引用本文： | 赵玲,杨博,梁敬钰.高良姜根茎的化学成分及抗口腔菌活性测定[J].武汉工业学院学报,2012,31(3):6-9. |
| 作者姓名： | 赵玲 杨博 梁敬钰 |
| 作者单位： | 1. 武汉工业学院生物与制药工程学院,湖北武汉,430023 2. 南京安格医药化工有限公司,江苏南京,210009 3. 中国药科大学天然药物化学教研室,江苏南京,210009 |
| 基金项目： | 武汉工业学院引进(培养)人才科研启动项目(2011RZ14) |
| 摘 要： | 对中药高良姜的化学成分进行研究,利用硅胶柱层析、SephadexLH-20柱层析及重结晶等方法进行分离纯化,得到黄酮及二苯庚烷类化合物共10个,通过波谱技术鉴定结构,并采用MTT法进行actinomyces viscosus ATCC 27044黏性放线菌和streptococcus mutans ATCC 25175变链球菌两种口腔菌的活性测定,结果显示仅化合物6对黏性放线菌有一定的抑菌活性,其余化合物均无明显活性. |
| 关 键 词： | 高良姜 化学成分 黄酮 二苯庚烷 抗口腔菌 |
Chemical constituents and anti-oral bacterium activities of the rhizomes of alpinia officinarum |
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| ZHAO Ling , YANG Bo , LIANG Jing-yu.Chemical constituents and anti-oral bacterium activities of the rhizomes of alpinia officinarum[J].Journal of Wuhan Polytechnic University,2012,31(3):6-9. | |
| Authors: | ZHAO Ling YANG Bo LIANG Jing-yu |
| Affiliation: | 1.School of Biology and Pharmaceutical Engineering,Wuhan Polytechnic University,Wuhan 430023,China; 2.Nanjing Ange Pharmaceutical Co.Ltd.,Nanjing 210009,China; 3.Department of Natural Medicinal Chemistry,China Pharmaceutical University,Nanjing 210009,China) |
| Abstract: | The chemical constituents of traditional Chinese medicine alpinia officinarum Hance were studied.Ten compounds including five flavone compounds and five diarylheptanoid compounds were isolated by silica gel chromatography,Sephadex LH-20 chromatography and crystallization,and their structures were elucidated on the basis of spectral analysis.Anti-oral bacterium activities including Actinomyces viscosus ATCC 27044 and streptococcus mutans ATCC 25175 were tested by MTT methods and all compounds showed no effects except compound 6 had some effect against Actinomyces viscosus ATCC 27044. |
| Keywords: | alpinia officinarum chemical constituents flavone diarylheptanoid anti-oral bacterium |
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