| 苯丙酮酸在Pd/C催化剂上还原胺化合成DL-苯丙氨酸 |
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| 引用本文： | 吴广文,李光兴,梅付名,纪元. 苯丙酮酸在Pd/C催化剂上还原胺化合成DL-苯丙氨酸[J]. 精细化工, 2001, 18(10): 579-581 |
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| 作者姓名： | 吴广文 李光兴 梅付名 纪元 |
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| 作者单位： | 华中科技大学化学系 |
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| 摘 要： | 以苯丙酮酸 (PPA)在Pd/C催化剂上还原胺化合成DL 苯丙氨酸 (Phe)。实验表明 :在 5 5℃、1 0MPa,苯丙酮酸初始质量浓度 ρ(PPA) =6 0g/L ,n(NH3)∶n(PPA) =3 0∶1 0 ,还原胺化 3h ,苯丙氨酸收率在 95 %以上 ,产品纯度w(DL Phe) >96 % ,并通过红外光谱、核磁共振对产物结构进行了确证
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| 关 键 词： | DL苯丙氨酸 苯丙酮酸 还原胺化 Pd/C催化剂 |
| 文章编号： | 1003-5214(2001)10-0579-03 |
Synthesis of DL-Phenylalanine from Phenylpyruvic Acid by Reduction Amination over Pd/C Catalyst |
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| WU Guang wen,LI Guang xing,MEI Fu ming,JI Yuan. Synthesis of DL-Phenylalanine from Phenylpyruvic Acid by Reduction Amination over Pd/C Catalyst[J]. Fine Chemicals, 2001, 18(10): 579-581 |
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| Authors: | WU Guang wen LI Guang xing MEI Fu ming JI Yuan |
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| Abstract: | Synthesis of DL phenylalanine (Phe) from phenylpyruvic acid (PPA) by reductive amination over Pd/C catalyst was studied.When the reaction was carried out at 55 ℃,1.0 MPa,3 h,initial concentration of phenylpyruvic acid ρ (PPA)=60 g/L,and mole ratio of NH-3·H-2O to phenlpyruvic acid = 3.0∶1.0,the yield of phenylalanine was greater than 95% with purity w(DL Phe)>96%.The structure of the product was characterized by IR and 1 HNMR spectra. |
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| Keywords: | DL phenylalanine phenylpyruvic acid reductive amination Pd/C catalyst |
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