| Inhibitory effect of low dose irradiation on tumor metastases in tumor bearing in mice |
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| 作者姓名： | 魏道严 金敖兴 黄帼 汪思应 左祥生 |
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| 作者单位： | Department of Nuclear Medicine，Anhui Medical University，Hefei 250052 |
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| 摘 要： | Ｉｎｈｉｂｉｔｏｒｙｅｆｆｅｃｔｏｆｌｏｗｄｏｓｅｉｒｒａｄｉａｔｉｏｎｏｎｔｕｍｏｒｍｅｔａｓｔａｓｅｓｉｎ ｔｕｍｏｒｂｅａｒｉｎｇｉｎｍｉｃｅＷｅｉＤａｏ－Ｙａｎ（魏道严）；ＪｉｎＡｏ－Ｘｉｎｇ（金敖兴）；ＨｕａｎｇＧｕｏ（黄帼）；ＷａｎｇＳｉ...
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| 关 键 词： | 肿瘤 低剂量辐照 肿瘤分解 变异 |
Inhibitory effect of low dose irradiation on tumor metastases in tumor bearing in mice |
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| Wei Dao-Yan,Jin Ao-Xing,Huang GuoWang Si-Ying and Zuo Xiang-Sheng.Inhibitory effect of low dose irradiation on tumor metastases in tumor bearing in mice[J].Nuclear Science and Techniques,1996,7(3):180-182. |
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| Authors: | Wei Dao-Yan Jin Ao-Xing Huang GuoWang Si-Ying and Zuo Xiang-Sheng |
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| Abstract: | By using the models of tumor blood-borne metastasis and spontaneous one,the antitumor metastasis effect of 75mGy X-ray whole body irradiation on tumor bearing mice is investigated. The results demonstrate that irradiation could significantly inhibit B16 melanoma blood borne pulmonary metastases (P<0.05)and Lewis lung carcinoma(LLC)spontaneous pulmonary metastases(P<0.01).The immunofunction test of B16 melanoma bearing mice shows that the NK (P<0.05) and LAK (P<0.001)cytotoxicities,and responsibility of splenocytes to IL-2 (P<0.005) for the irradiated group are increased greatly compared with those of control group.These results suggest that the enhancement of immunofunctions is induced by low dose radiation to raise antitumor metastasis effects. |
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| Keywords: | Low dose radiation Metastasis of neoplasm Mice X-rays |
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