Mechanical,setting, and biological properties of bone cements containing micron-sized titania particles |
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Authors: | Koji Goto Masami Hashimoto Hiroaki Takadama Jiro Tamura Shunsuke Fujibayashi Keiichi Kawanabe Tadashi Kokubo Takashi Nakamura |
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Affiliation: | (1) Department of Orthopaedic Surgery, Faculty of Medicine, Kyoto University, Kawahara-cho 54, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan;(2) Japan Fine Ceramics Center, Mutsuno 2-4-1, Atsuta-ku, Nagoya 456-8587, Japan;(3) Research Institute for Science and Technology, Chubu University, 1200 Matsumoto-cho, Kasugai 487-8501, Japan |
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Abstract: | In this study, polymethylmethacrylate-based composite cements containing 40–55.6 wt% micron-sized titania (titanium oxide) particles were developed, and their mechanical, setting, and biological properties evaluated. Three types of composite cement containing 40, 50, and 55.6 wt% silanized titania were designated ST2-40c, ST2-50c, and ST2-56c, respectively. In animal experiments, ST2-50c and ST2-56c were implanted into rat tibiae and solidified in situ. An affinity index was used to evaluate osteoconductivity. Compressive and bending strength of ST2-56c was 147.7 ± 3.2 and 69.3 ± 7.4; those of the other cements exceeded 100 MPa and 50 MPa, respectively. The affinity indices of ST2-56c were 42.1 ± 12.9 at six weeks and 53.4 ± 16.6 at 12 weeks, and were significantly higher than for ST2-50c and a commercial PMMA bone cement within 12 weeks. Our data indicate that bone cement containing micron-sized titania particles can be applied to prosthesis fixation as well as vertebroplasty, and ST2-56c is a good candidate cement. |
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