| 稳定同位素标记恩诺沙星-D5的合成 |
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| 引用本文： | 徐仲杰,卢伟京,卢浩.稳定同位素标记恩诺沙星-D5的合成[J].精细化工,2012,29(11):1050-1052,1077. |
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| 作者姓名： | 徐仲杰 卢伟京 卢浩 |
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| 作者单位： | 上海化工研究院,上海化工研究院,上海化工研究院 |
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| 基金项目： | 科技部转制院所专项(2011EG116066)。 |
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| 摘 要： | 该文提出简便的、丰度不稀释的方法合成恩诺沙星-D5,即以乙醇-D6为合成前体,与碘反应得到碘乙烷-D5,再进一步与环丙沙星烷基化生成目标产物。以消耗的乙醇-D6计算,恩诺沙星-D5总收率为69.9%。产品结构经质谱和核磁共振波谱等表征确定,D的同位素丰度为99.6%,色谱纯度为99.0%,可作为食品安全领域检测用同位素内标试剂。
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| 关 键 词： | 稳定同位素标记 恩诺沙星 功能材料 |
| 收稿时间： | 2012/8/10 0:00:00 |
| 修稿时间： | 9/4/2012 12:00:00 AM |
Syntheses of Labeled Enrofloxacin-D5 |
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| XU Zhong-jie,LU Wei-jing and LU Hao.Syntheses of Labeled Enrofloxacin-D5[J].Fine Chemicals,2012,29(11):1050-1052,1077. |
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| Authors: | XU Zhong-jie LU Wei-jing and LU Hao |
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| Affiliation: | Shanghai Research Institute of Chemical Industry,Shanghai Research Institute of Chemical Industry |
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| Abstract: | This article presents an efficient and no-dilution of isotopic enrichment method for the synthesis of labeled standard enrofloxacin-D5,with CD3CD2OD as the common substrate.Iodination of CD3CD2OD with I2 provided CD3CD2I,which was subsequently used to ethylate ciprofloxacin to get enrofloxacin-D5.The yield of enrofloxacin-D5 was 69.9% based on CD3CD2OD consumed.The product was confirmed by NMR and LC-MS to be the target compound.Its chemical purity was 99.0% and isotopic enrichment of D was 99.6%.It could be used as internal standard in the field of food safety testing. |
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| Keywords: | stable isotope labelled enrofloxacin synthesis functional materials |
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