Preparation and cytocompatibility of chitosan‐modified polylactide |
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| Authors: | Yumei Xiao Dongxiao Li Xuening Chen Jian Lu Hongsong Fan Xingdong Zhang |
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| Affiliation: | 1. Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China;2. Sichuan Institute of Chinese Materia Medica, Chengdu 610041, China |
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| Abstract: | Chitosan‐modified PLA (CMPLA) was fabricated to improve cytocompatibility of polylactide (PLA). PMAA‐grafted PLA (PMAA‐PLA) was obtained through α‐methacrylic acid (MAA) grafted polymerization on PLA surface with photooxidization and UV irradiation. Steady PMAA‐PLA microparticle suspension with an average size as 172.8 ± 3.6 nm and zeta potential as ?95.0 ± 0.6 mV was prepared through solvent volatilization. By static electricity interaction and other interactions between PMAA‐PLA microsparticles and chitosan molecules, CMPLA was obtained. FTIR, XPS, SEM, and zeta potential analyses indicated that CMPLA was modified with chitosan molecules uniformly. Compared with the PLA control, CMPLA adapted to supporting the attachment and proliferation of L929 cells better. The obtained CMPLA was expected to be used as perfect biomaterial for tissue regeneration. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008 |
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| Keywords: | polylactide chitosan microspheres surface modification cytocompatibility |
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