| 合成芥子酸胺盐衍生物的辐射防护机理研究 |
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| 引用本文： | 黄振东,王礼嫝,董欣,林念芸. 合成芥子酸胺盐衍生物的辐射防护机理研究[J]. 辐射研究与辐射工艺学报, 1986, 0(3) |
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| 作者姓名： | 黄振东 王礼嫝 董欣 林念芸 |
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| 作者单位： | 上海市放射医学研究所(黄振东，王礼嫝，董欣)，中国科学院上海原子核研究所(林念芸) |
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| 摘 要： | 为了寻找有效的辐射损伤防护药,改进及新合成芥子酸及胺盐衍生物,用ESR波谱研究电子从靶分子脱氧胸腺嘧啶核苷酸(dTMP)向芥子酸长程转移的保护机理。经辐照小鼠的试验表明:辐照损伤引起的外周血小板下降症可以被芥子酸胺盐衍生物保护。并报道了芥子酸类衍生物的红外及核磁共振光谱。
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| 关 键 词： | 辐射防护药 芥子酸合成 电荷转移 ESR波谱 提高血小板 |
STUDIES ON RADIOPROTECTION MECHANISM BY SYNTHETIC SINAPIC ACID AMINE SALT DERIVATIVES |
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| Huang Zhentong,Wang Likang,Dong Xin,Lin Nianyun. STUDIES ON RADIOPROTECTION MECHANISM BY SYNTHETIC SINAPIC ACID AMINE SALT DERIVATIVES[J]. Journal of Radiation Research and Radiation Processing, 1986, 0(3) |
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| Authors: | Huang Zhentong Wang Likang Dong Xin Lin Nianyun |
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| Affiliation: | Huang Zhentong,Wang Likang,Dong Xin,Lin Nianyun Shanghai Institute of Radiation Medicine Institute of Nuclear Research,Academia Sinica,Shanghai,China |
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| Abstract: | In order to find more effective radioprotector, an improved newmethod to synthesis sinapic acid and its amine salt derivatives has been reported, andthe study of ESR spectra from sinapic acid-dTMP with molar ratio 1:10 irradiatedand recorded at 77 K has confirmed the long range electron transfer from thymine ofdTMP to sinapic acid:also, the radioprotective effect of sinapic acid amine salt derivatives on irradiated mice(500 rad.) has been shown in increasing peripheral platelet count with significance ofstatistics. The I. R and NMR spectra of sinapic acid derivatives also have been repor-ted. |
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| Keywords: | Radioprotector Synthesis of Sinapic Acid Charge Transfer ESR Platelet Increasing |
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