Polyphosphoester‐based paclitaxel complexes |
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| Authors: | Violeta Mitova Tatyana Hristova Rumyana Cherkezova Neli Koseva Shin‐ichi Yusa Kolio Troev |
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| Affiliation: | 1. Laboratory of Phosphorus-containing Monomers and Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Sofia, Bulgaria;2. Department of Medico-biological Sciences, Мedical University—Varna, Faculty of Dental Medicine, Varna, Bulgaria;3. Department of Materials Science and Chemistry, University of Hyogo, Hyogo, Japan |
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| Abstract: | We demonstrated a feasible approach for the preparation of a biodegradable, water soluble polyphosphoester based paclitaxel complex. Applying poly(hydroxyoxyethylene phosphate) which contains both a strong proton accepting P?O group and a proton donating P? OH group, paclitaxel has been physically immobilized onto the polymer via H‐bonding. The water soluble complex contained 16.7 wt % paclitaxel and more than 4000 times increased drug solubility was achieved. The polymer‐drug complex formed nanosized aggregates that were characterized by dynamic light scattering. Intravenous injection of poly(hydroxyoxyethylene phosphate) in rats at a dose of 1000 mg/kg did not induce any clinical signs or body weight gain reduction. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132, 42772. |
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| Keywords: | biocompatibility biomedical applications hydrophilic polymers light scattering |
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