| Heparosan对几株肠道致病菌黏附特性的影响 |
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| 引用本文： | 陈祥娥,段荣帅,凌沛学. Heparosan对几株肠道致病菌黏附特性的影响[J]. 食品与药品, 2011, 0(9): 309-312 |
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| 作者姓名： | 陈祥娥 段荣帅 凌沛学 |
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| 作者单位： | 山东大学药学院;山东省生物药物研究院博士后科研工作站;山东商业职业技术学院; |
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| 摘 要： | 目的研究肝素前体heparosan对肠道致病菌黏附特性的影响。方法选取几株常见的可引起肠道感染的致病菌株,以HT-29细胞系和固定化黏蛋白作为黏附受体,测定不同浓度heparosan对黏附细菌总数的影响,并进行统计分析。结果 heparosan可显著减少部分致病菌对HT-29细胞层和黏蛋白层的黏附。结论 heparosan可抑制部分肠道致病菌的黏附。
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| 关 键 词： | heparosan 肠道致病菌 黏附 |
Influence of Heparosan to the Adhesive Properties of Several Selected Entero-Pathogens |
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| CHEN Xiang-e,,DUAN Rong-shuai,,LING Pei-xue. Influence of Heparosan to the Adhesive Properties of Several Selected Entero-Pathogens[J]. Food and Drug, 2011, 0(9): 309-312 |
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| Authors: | CHEN Xiang-e DUAN Rong-shuai LING Pei-xue |
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| Affiliation: | CHEN Xiang-e1,2,DUAN Rong-shuai1,3,LING Pei-xue1,2(1.School of Pharmaceutical Science,Shandong University,Jinan 250012,China,2.Postdoctoral Scientific Research Workstation,Institute of Biopharmaceuticals of Shandong Province,Jinan 250101,3.Shandong Institute of Commerce and Technology,Jinan 250103,China) |
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| Abstract: | Objective To investigate the effect of heparosan on the adhesive properties of enteric pathogens.Methods Several strains of common bacteria that cause intestinal infection were selected,and HT-29 cell enterocytes and immobilized mucin were used as the adhesion receptors to determine the influence of different concentrations of heparosan on the adhesion of the total number of bacteria with statistical analysis.Results Heparosan significantly reduced the adhesion of certain pathogenic bacteria to HT-29 cell e... |
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| Keywords: | heparosan enteric pathogen adhesion |
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