| 药物缓释材料的合成与性能 |
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| 引用本文： | 唐明义,耿奎士,巩运兰,牛月兰,方静,丁宏远,王凤玲.药物缓释材料的合成与性能[J].合成树脂及塑料,1998(4). |
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| 作者姓名： | 唐明义 耿奎士 巩运兰 牛月兰 方静 丁宏远 王凤玲 |
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| 作者单位： | 天津商学院食品系 300400
(唐明义，耿奎士，巩运兰，牛月兰，方静，丁宏远)，天津商学院食品系 300400(王凤玲) |
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| 摘 要： | 研究了聚氨酯/聚醚半互穿网络聚合物的合成、溶胀行为和释放性能,特别是疏水组成、线型聚醚结构和温度对网络的溶胀平衡和溶胀动力学的影响。同时还测量了大分子肝素在填充时的分配系数和释放速度,并对肝素从溶胀的互穿网络聚合物中释放的机理进行了讨论。
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| 关 键 词： | 热敏性 平衡溶胀比 分配系数 解溶胀动力学 |
Synthesis and Properties of Thermosensitive Material Used for Controlled Releasing of Medicine |
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| Tang Mingyi,Geng Kuishi,Gong Yunlan,Niu Yuelan,Fang Jing,Ding Hongyuan,Wang Fengling.Synthesis and Properties of Thermosensitive Material Used for Controlled Releasing of Medicine[J].China Synthetic Resin and Plastics,1998(4). |
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| Authors: | Tang Mingyi Geng Kuishi Gong Yunlan Niu Yuelan Fang Jing Ding Hongyuan Wang Fengling |
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| Abstract: | This paper studied synthesis, swelling behaviour and release properties of PU/PEG semi - IPNs. It was found that hydrophobic component and structure of the linear polyether exerted influences upon the swelling equilibrium and deswelling kinetics of the networks. Partition coefficient and release speed of macromolecular heparin was also measured as function of temperature and network composition. The release mechanism of the heparin from the swollen semi - IPN was discussed. |
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| Keywords: | thermosensitive equilibrium swelling ratio partition coefficient deswelling kinetics |
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