Biotransformation of linoleic acid by Clavibacter sp. ALA2: Heterocyclic and heterobicyclic fatty acids |
| |
Authors: | Harold W Gardner Ching T Hou David Weisleder Wanda Brown |
| |
Affiliation: | (1) Bioactive Agents Research, ARS, USDA, 61604 Peoria, Illinois;(2) Oil Chemical Research, ARS, USDA, 1815 N. University Street, 61604 Peoria, Illinois;(3) Analytical Chemical Services, National Center for Agricultural Utilization Research, ARS, USDA, 61604 Peoria, Illinois |
| |
Abstract: | Clavibacter sp. ALA2 transformed linoleic acid into a variety of oxylipins. In previous work, three novel fatty acids were identified,
(9Z)-12,13,17-trihydroxy-9-octadecenoic acid and two tetrahydrofuran-(di)hydroxy fatty acids. In this report, we confirm the
structures of the tetrahydrofuran-(di)hydroxy fatty acids by nuclear magnetic resonance as (9Z)-12-hydroxy-13,16-epoxy-9-octadecenoic acid and (9Z)-7,12-dihydroxy-13,16-epoxy-9-octadecenoic acid. Three other products of the biotransformation were identified as novel heterobicyclic
fatty acids, (9Z)-12,17;13,17-diepoxy-9-octadecenoic acid, (9Z)-7-hydroxy-12,17;13,17-diepoxy-9-octadecenoic acid, and (9Z)-12,17;13,17-diepoxy-16-hydroxy-9-octadecenoic acid. Thus, Clavibacter ALA2 effectively oxidized linoleic acid at C-7,-12,-13,-16, and/or-17. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|