| 四氟醚菊酯的合成 |
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| 引用本文： | 贺书泽. 四氟醚菊酯的合成[J]. 现代农药, 2014, 0(6): 22-24 |
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| 作者姓名： | 贺书泽 |
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| 作者单位： | 江苏扬农化工股份有限公司,江苏扬州225009 |
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| 摘 要： | 优化反应条件,以四氟对苯二甲酸二甲酯、硼氢化钾、硫酸二甲酯等为原料,经还原和醚化反应制得关键中间体2,3,5,6-四氟-4-甲氧甲基苄醇,该中间体再与2,2,3,3-四甲基环丙烷甲酰氯发生缩合反应制得目标产物四氟醚菊酯。以四氟对苯二甲酸二甲酯计,3步总收率为76.7%,产品质量分数超过96%。该路线反应条件温和、收率高,适合工业生产。
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| 关 键 词： | 2,3,5,6-四氟-4-甲氧甲基苄醇 四氟醚菊酯 合成 |
Synthesis of Tetramethylfluthrin |
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| HE Shu-ze. Synthesis of Tetramethylfluthrin[J]. Modern Agrochemicals, 2014, 0(6): 22-24 |
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| Authors: | HE Shu-ze |
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| Affiliation: | HE Shu-ze (Jiangsu Yangnong Chemical Co., Ltd., Jiangsu Yangzhou 225009, China) |
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| Abstract: | 4-Methoxymethyl-2,3,5,6-tetrafluorobenzyl alcohol is an important imtermediate of tetramethylfluthrin, the imtermediate was prepared via reduction reaction, etherification reaction with dimethyl tetrafluoroterephthalate, potassium borohydride and dimethylsulfate as starting materials. Then 4-methoxymethyl-2,3,5,6-tetrafluorobenzyl alcohol reacted with 2,2,3,3-tetramethyl cyclopropane carboxynyl chloride. The total yield was 76.7%, and the purity of the produce was above 96%. |
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| Keywords: | 4-methoxymethyl-2 3 5 6-tetrafluorobenzyl alcohol tetramethylfluthrin synthesis |
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