壳聚糖/聚乙烯醇/壳寡糖抑菌纳米纤维膜的制备和性能研究

以壳聚糖（CS）为基材，使用静电纺丝的方法制备了搭载壳寡糖（CHOS）的CS/聚乙烯醇（PVA）/CHOS纳米纤维膜，并对纳米纤维膜的微观形貌、结构、抑菌性、亲水性以及溶解性能进行了研究。研究发现：CS/PVA/CHOS纳米纤维膜具备均匀密致的微观形貌；FT-IR测试表明，CHOS以物理混合的形式分散在CS/PVA/CHOS纳米纤维膜中；XRD测试表明，CHOS的加入改变了纳米纤维膜的结晶性，促进了各组分之间的相容性；水接触角测试表明纳米纤维膜具备良好的亲水性，在m（CS）：m（PVA）：m（CHOS）=20：80：10时，CS/PVA/CHOS纳米纤维膜的接触角相比于m（CS）：m（PVA）=20：80的CS/PVA纳米纤维膜由59.8°下降到37.5°；抑菌性能和溶解性能测试表明，m（CS）：m（PVA）：m（CHOS）=20：80：10时的CS/PVA/CHOS纳米纤维膜相比于未搭载CHOS的CS/PVA纳米纤维膜，抑菌性提升了38.9%，溶解率提升了38.6%。

Preparation and Properties of Bacteriostatic Chitosan/PVA/Chitosan Oligosaccharide Nanofibrous Membranes

Chitosan(CS)/polyvinyl alcohol(PVA)/chitosan oligosaccharide(CHOS) nanofibrous membrane was prepared by electrospinning. The morphology, structure, bacteriostasis, hydrophilicity and solubility of the membrane were studied. Scanning electron microscope(SEM) observation showed that CS/PVA/CHOS nanofibrous membrane had uniform and dense micro morphology. FT-IR test showed that CHOS was dispersed in CS/PVA/CHOS nanofibrous membrane in the form of physical mixing. XRD test showed that the addition of CHOS changed the crystallinity of the nanofibrous membrane and promoted the compatibility between components. Water contact angle test showed that the nanofibrous membrane had good hydrophilicity. As the mass ratio of CS, PVA and CHOS was 20:80:10, the water contact angle of CS/PVA/CHOS nanofibrous membrane decreased from 59.8° to 37.5° compared with that of CS/PVA nanofibrous membrane with the mass ratio of CS and PVA 20:80. Bacteriostatic test and solubility test showed that CS/PVA/CHOS nanofibrous membrane with mass ratio of CS, PVA and CHOS 20:80:10 were better than those of CS/PVA nanofibrous membrane without CHOS, the bacteriostasis and solubility increased 38.9% and 38.6%, respectively.