| 邻菲罗啉的99mTc和188Re标记化学的研究 |
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| 引用本文： | 包安德,陆丽仪,王学斌,秦林林. 邻菲罗啉的99mTc和188Re标记化学的研究[J]. 核技术, 1999, 22(4): 253-256 |
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| 作者姓名： | 包安德 陆丽仪 王学斌 秦林林 |
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| 作者单位： | 1. 北京市中日友好医院临床医学研究所,北京,100029
2. 北京师范大学,北京,100875 |
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| 摘 要： | 以ＳｎＣｌ２作还原剂，酒石酸钠钾作中间络合剂，以纸层析法通过三种展开体系，研究了邻菲罗啉（Ｐｈｅｎ）的＾９９ｍＴｃ、１８８Ｒｅ和稳定铼标记化学，并用离子交换法对＾９９ｍＴｃ－Ｐｈｅｎ的表观电荷进行了测定。结果显示，＾９９ｍＴｃ－Ｐｈｅｎ标记率可达９５％以上；在ｐＨ１．０、沸水浴标记条件下，＾９９ｍＴｃ－Ｐｈｅｎ为两种或两种以上不同结构标记物的混合物；在ｐＨ５．０、室温标记条件下，＾９９ｍＴｃ－Ｐｈ
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| 关 键 词： | 邻菲罗啉 99mTc标记 188Re标记 稳定铼标记 纸层析法 表观电荷 |
Research on labelling chemistry of o-Phenanthroline with 99mTc,188Re and stable Re |
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| BAO Ande,LU Liyi,WANG Xuebin,QIN Linlin. Research on labelling chemistry of o-Phenanthroline with 99mTc,188Re and stable Re[J]. Nuclear Techniques, 1999, 22(4): 253-256 |
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| Authors: | BAO Ande LU Liyi WANG Xuebin QIN Linlin |
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| Abstract: | With SnCl2 as reductant, tartrate as intermediate ligand, and with the aid of paper chromatography on three kinds of developing agents, the 99mTo, 188Re and stable rhenium labelling chemistry with regard to o-phenanthroline (Phen) have been studied. The labelling ratio of 99mTc-Phen can reach to 95%. For different pH values of media and at different labelling temperatures, the 99mTo-Phen products can be different, and they can have different paper chromatographic behavior in some developing agents. The labelling of 188Re and stable rhenium is more difficult than that of 99mTc. Even if large quantity of SnCl2 is used, the labelling ratio of 188Re-phen is singnificantly lower than 99mTo-Phen: the highest labelling ratio is only 50%. |
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| Keywords: | o-Phenanthroline ~(99m)To labelling ~(188)Re labelling Stable Re labelling Paper chromatography Apparent charge number |
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