| 应用99mTc-NGA进行肝ASGP受体显像的实验研究 |
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| 引用本文： | 陶永辉,张荣军,胡名扬,万卫星,谭成,张莲芬,蔡刚明,王博诚,金坚. 应用99mTc-NGA进行肝ASGP受体显像的实验研究[J]. 核技术, 1999, 22(11): 663-667 |
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| 作者姓名： | 陶永辉 张荣军 胡名扬 万卫星 谭成 张莲芬 蔡刚明 王博诚 金坚 |
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| 作者单位： | 江苏省原子医学研究所,核医学国家重点实验室,无锡,214063 |
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| 基金项目： | 江苏省卫生厅科研基金!149533 |
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| 摘 要： | 新半乳糖人血清白蛋白（ＮＧＡ）是肝细胞表面去唾液酸糖蛋白受体（ＡＳＧＰＲ）的特异性配基。根据受体与配基结合的原理,报道了以＾９９ｍＴｃ标记的人血清白蛋白（ＨＳＡ）在正常兔中显像行为的对比。结果表明＾９９ｍＴｃ－ＨＳＡ呈现血池显像剂的行为,而＾９９ｍＴｃ－ＮＧＡ则呈现肝脏受体显像剂的行为,并且若兔事先用１００倍量未标记的ＮＧＡ将肝脏受体饱和后,再用＾９９ｍＴｃ－ＮＧＡ显像则呈现与＾９９ｍＴｃ－ＨＳＡ
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| 关 键 词： | ASGP受体显像 血池显像 流式细胞分析 |
Hepatic ASGP receptor image of 99mTc-NGA in normal rabbit |
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| TAO Yonghui,ZHANG Rongjun,HU Mingyang,WAN Weixing,TAN Cheng,ZHANG Lianfeng,CAI Gangming,WANG Bocheng,JIN Jian. Hepatic ASGP receptor image of 99mTc-NGA in normal rabbit[J]. Nuclear Techniques, 1999, 22(11): 663-667 |
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| Authors: | TAO Yonghui ZHANG Rongjun HU Mingyang WAN Weixing TAN Cheng ZHANG Lianfeng CAI Gangming WANG Bocheng JIN Jian |
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| Abstract: | Galactosylneoglycoalbumin (NGA) is aspecific ligand of asialoglycoproteinreceptor (ASGPR) in hepatocyte surface.In this paper,the imaging comparison of~99mTc-NGA and ~99mTc-HSA in normal rabbit imaging are reported. ~99mTo-HSAgenerated a blood pool image when injected into normal rabbit, while ~99mTo-NGAshowed a hepatic receptor image charateristics. If rabbit hepatic receptor had beensaturated with 100 times amounts of NGA, ~99mTc-NGA would generate a blood poolimaging sunilar to ~99mTc-HSA. Flow cytometry (FCM) analysis with FITC-NGA alsoshowed that ASGPR could be obviously saturated. Therefore, ~99mTc-NGA is ahepatic receptor image agent. |
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| Keywords: | 99mTc-NGA 99mTc-HSA |
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