Reciprocal interactions between resveratrol and gut microbiota deepen our understanding of molecular mechanisms underlying its health benefits |
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| Affiliation: | 1. Department of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan;2. School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan;3. Department of Seafood Science, National Kaohsiung University of Science and Technology, Kaohsiung, Taiwan;4. Center for Environmental Toxin and Emerging-Contaminant Research, Cheng Shiu University, Kaohsiung, Taiwan;5. Super Micro Mass Research and Technology Center, Cheng Shiu University, Kaohsiung, Taiwan;6. Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan;7. Division of Nephrology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan;8. Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan;1. Department of Biochemistry and Biomedical Sciences and Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada;2. Department of Medicine, Faculty of Medicine, Cardiology Axis of the Québec Heart and Lung Institute and Institute of Nutrition and Functional Foods, Laval University, Québec City, QC, Canada;3. Cardiovascular Research Centre, Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada |
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| Abstract: | BackgroundResveratrol is a stilbene-based phytochemical, which possesses multiple pharmacological activities. However, the low bioavalibility of resveratrol mystifies its pharmacology.Scope and approachWe discussed the reciprocal interactions of resveratrol with gut microbiota as investigated by in vitro, animal models as well as humans studies.Key findings and conclusionsThe first part described the current in vitro and in vivo evidence concerning the modulative effect of resveratrol on gut microbiota composition, particularly focusing on the involvement of gut microbiota modulation in the anti-diabetic, anti-obesity, and anti-atherosclerosis effects of resveratrol. The second part summarized the bioconversion of resveratrol by gut microbiota, and the identification of metabolites along with bacterial species as generators of these metabolites. This may not only help reconcile the bioavailability conundrum of resveratrol, but also provide directions to expedite its medical applications. |
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| Keywords: | Resveratrol Gut microbiota Modulation Bioconversion |
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